Family

WD repeat domain phosphoinositide-interacting protein 4 (IPR032910)

Short name: WIPI4

Overlapping homologous superfamilies

Family relationships

None.

Description

WD repeat domain phosphoinositide-interacting protein 4 (WIPI4, also known as WDR45) is one of the four mammalian homologues of yeast Atg18, which has an important role in autophagy. In C.elegans the WIPI4 homologue, EPG-6, has been shown to regulate progression of omegasomes to autophagosomes [PMID: 21802374]. Mutations in the WDR45 gene cause the neurodegenerative disease NBIA (neurodegeneration with brain iron accumulation) [PMID: 23435086].

GO terms

Biological Process

GO:0006914 autophagy

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER