Vacuole morphology and inheritance protein 14, Fab1-binding region (IPR032878)

Short name: Vac14_Fab1-bd

Overlapping homologous superfamilies

Domain relationships



This entry represents the Fab1-binding region of Vac14.

Vac14 is a component of the PI(3,5)P2 regulatory complex, which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) [PMID: 19037259]. This complex is composed of Atg18, Fig4, Fab1, Vac14 and Vac7 in yeast. In mammals it consists of PIKfyve, FIG4 and VAC14. Fab1/PIKfyve (Fab1 in yeast and PIKfyve in mammals) is a kinase that converts PI(3)P into PI(3,5)P2 by phosphorylation at the 5-position; conversely Fig4 dephosphorylates PI(3,5)P2 back to PI(3)P. Vac14 is a scaffolding adaptor protein whose multimerisation is a prerequisite step for PI(3,5)P2 complex assembly and function [PMID: 23389034].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.