Alkylated DNA repair protein alkB homologue 8 (IPR032863)

Short name: ALKBH8

Overlapping homologous superfamilies

Family relationships



Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [PMID: 26152727, PMID: 26003568].

AlkB homologue 8 (ALKBH8) is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival [PMID: 20308323, PMID: 21285950]. It contains an N-terminal RNA recognition motif (RRM) and a predicted C-terminal methyltransferase domain fused to the central AlkB homologous domain [PMID: 20583019]. ALKBH8 and tRNA modifications seem to be central regulators of cellular oxidative stress responses in mammalian systems [PMID: 26147969]. ALKBH8 is expressed in various types of human cancers [PMID: 19293182].

GO terms

Biological Process

GO:0030488 tRNA methylation
GO:0002098 tRNA wobble uridine modification

Molecular Function

GO:0016300 tRNA (uracil) methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.