RNA demethylase ALKBH5 (IPR032860)

Short name: ALKBH5

Overlapping homologous superfamilies

Family relationships



Based on homology with E. coli AlkB, nine mammalian AlkB homologues have been identified. Like E. coli AlkB, ALKBH2 and ALKBH3 have been shown to possess DNA repair activity. However, findings suggest a wide functional diversity for other mammalian AlkB proteins, with substrates ranging from DNA and RNA to protein [PMID: 26152727, PMID: 26003568].

ALKBH5 is an dioxygenase that has been shown to specifically demethylate m(6)A in single-stranded RNA [PMID: 23177736, PMID: 24778178, PMID: 24489119]. Reversible m(6)A modification is one of the most abundant RNA modifications, and is probably involved in broad and fundamental functions in mammalian cells [PMID: 23177736]. ALKBH5 may have a role in the regulation of cellular responses to hypoxia [PMID: 21264265].

GO terms

Biological Process

GO:0006397 mRNA processing
GO:0035553 oxidative single-stranded RNA demethylation

Molecular Function

GO:0035515 oxidative RNA demethylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.