Alkylated DNA repair protein alkB homologue 3 (IPR032854)

Short name: ALKBH3

Overlapping homologous superfamilies

Family relationships



AlkB proteins are dioxygenases that repair alkylation damage to DNA and RNA [PMID: 12594517]. Nine mammalian AlkB homologues exist (ALKBH1-8, FTO), but only a subset functions as DNA/RNA repair enzymes [PMID: 26152727].

This entry represents AlkB homologue 3 (ALKBH3, ABH3), which has a strong preference for single-stranded DNA also demethylates 1-methyladenine (1meA) and 3-methylcytosine (3meC) in RNA [PMID: 12594517, PMID: 15229293, PMID: 16858410]. ALKBH3 is overexpressed in various cancers and contributes to cancer cell survival [PMID: 22850567, PMID: 21285982, PMID: 26221185].

GO terms

Biological Process

GO:0006307 DNA dealkylation involved in DNA repair
GO:0006281 DNA repair
GO:0035552 oxidative single-stranded DNA demethylation

Molecular Function

GO:0051213 dioxygenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.