Transcription factor GLI3 (IPR032851)
Short name: GLI3
Overlapping homologous superfamilies
GLI3 is a member of the GLI family of transcription factors, which also includes GLI1 and GLI2. They are central effectors of the Hedgehog (Hh) pathway in vertebrates [PMID: 21801010, PMID: 20360384]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions [PMID: 15983404]. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [PMID: 10693759, PMID: 17400206, PMID: 12435361, PMID: 12435629, PMID: 26464005].
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0048568 embryonic organ development
GO:0006355 regulation of transcription, DNA-templated
GO:0007224 smoothened signaling pathway
GO:0003700 DNA binding transcription factor activity
No terms assigned in this category.
- PTHR19818:SF5 (PTHR19818:SF5)