Transcription factor GLI3 (IPR032851)

Short name: GLI3

Overlapping homologous superfamilies


Family relationships



GLI3 is a member of the GLI family of transcription factors, which also includes GLI1 and GLI2. They are central effectors of the Hedgehog (Hh) pathway in vertebrates [PMID: 21801010, PMID: 20360384]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions [PMID: 15983404]. The full-length GLI3 form, after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while its C-terminally truncated form acts as a repressor (GLI3R). GLI3 participates in the patterning and growth of many organs, including the central nervous system (CNS) and limbs [PMID: 10693759, PMID: 17400206, PMID: 12435361, PMID: 12435629, PMID: 26464005].

GO terms

Biological Process

GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0048568 embryonic organ development
GO:0006355 regulation of transcription, DNA-templated
GO:0007224 smoothened signaling pathway

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.