Zinc finger protein GLI1 (IPR032850)

Short name: GLI1

Overlapping homologous superfamilies


Family relationships



GLI1 (glioma-associated oncogene homologue 1) is a central effector of the Hedgehog (HH) pathway, a pathway that governs many developmental processes [PMID: 19081070]. It is a member of the GLI family of transcription factors, which also includes GLI2 and GLI3 [PMID: 21801010]. GLI1 is an obligatory activator, whereas GLI2 and GLI3 carry activator and repressor functions [PMID: 15983404]. GLI1 is amplified in a subset of human tumours [PMID: 19706761]. It contains five repeats of a zinc finger DNA-binding motif and binds DNA in a sequence-specific fashion [PMID: 2105456, PMID: 8378770].

GO terms

Biological Process

GO:0008284 positive regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0007224 smoothened signaling pathway

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.