Cleavage inducing molecular chaperone, Jiv (IPR032843)

Short name: Jiv

Overlapping homologous superfamilies


Domain relationships



This entry represents Jiv (J-domain protein interacting with viral protein), a domain found in the DnaJ protein from eukaryotes [PMID: 11533209]. It can also be found in the N-terminal region of the pestivirus viral polypeptide. The viral protein interacts stably with non structural (NS) protein NS2, causing a conformational change in NS2-NS3 and stimulates NS2-NS3 cleavage in trans. Cleavage of NS2-NS3 increases cytopathogenicity and consequently aids viral replication. Jiv therefore acts as a regulating cofactor for NS2 auto-protease. The efficient release of NS3 from the viral polypeptide by Jiv is considered crucial to the pestivirus cytopathogenicity [PMID: 12970452]. In eukaryotes, it usually lies 40 residues downstream of DnaJ domain (IPR001623). However, the function of this domain in eukaryotes is still unknown.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.