Domain

G2 and S phase-expressed protein 1, N-terminal (IPR032768)

Short name: GTSE1_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the N terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localised to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis [PMID: 12750368, PMID: 20577264]. This domain is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam