Family

Roquin-1 (IPR032671)

Short name: RC3H1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Roquin-1 (RC3H1) is a post-transcriptional repressor required to repress follicular helper T cells (Tfh) and autoimmunity [PMID: 15917799]. It binds to messenger RNAs (mRNAs) and regulates gene expression posttranscriptionally. For instance, it controls ICOS (inducible costimulator) expression through binding to the 3' UTR of ICOS mRNA and by interacting with proteins that confer post-transcriptional repression [PMID: 20639877]. Besides ICOS, it also represses Ox40 and interferon-gamma in T cells, and this helps to prevent inappropriate T cell activation and Tfh cell differentiation [PMID: 23583643, PMID: 23583642].

Roquin-1 and its paralogue, Roquin-2 (Rc3h2), have been found to redundantly repress the mRNAs controlling T follicular helper cells and systemic inflammation [PMID: 23583642, PMID: 23583643]. Tfhs are helper T-cells specialised in facilitating B-cell responses [PMID: 25261207].

GO terms

Biological Process

GO:0010608 posttranscriptional regulation of gene expression
GO:0050863 regulation of T cell activation
GO:0042129 regulation of T cell proliferation

Molecular Function

GO:0003730 mRNA 3'-UTR binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER