Roquin-2 (IPR032670)

Short name: RC3H2

Overlapping homologous superfamilies


Family relationships



Roquin-2 is an E3 ubiquitin ligase required for ROS-induced ubiquitination and degradation of ASK1 (Apoptosis signal-regulating kinase 1) [PMID: 24448648]. It also mediates mRNA deadenylation by recognising a conserved class of stem-loop RNA degradation motifs [PMID: 23663784]. Its structure has been revealed [PMID: 26249698].

Roquin-2 and its paralogue, Roquin-1 (Rc3h1), have been found to redundantly repress the mRNAs controlling T follicular helper cells and systemic inflammation [PMID: 23583642, PMID: 23583643].

GO terms

Biological Process

GO:0010608 posttranscriptional regulation of gene expression
GO:0016567 protein ubiquitination

Molecular Function

GO:0003729 mRNA binding
GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.