Pathways & interactions
Protein atonal homologue 7 (IPR032663)
Short name: Atoh7
Overlapping homologous superfamilies
- Helix-loop-helix DNA-binding domain superfamily (IPR036638)
Protein atonal homologue 7 (Atoh7, also known as Math5) is a basic helix-loop-helix transcription factor that is involved in early stages of retinal neurogenesis [PMID: 9806930, PMID: 21441919]. It is specifically expressed in the embryonic neural retina and is required for the genesis of retinal ganglion cells (RGCs) and optic nerves [PMID: 22645276].
This entry also includes Xenopus atonal homologue 5 (Xath5), which is involved in the differentiation of retinal ganglion cells and olfactory receptor neurons [PMID: 12454929].
The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].
- PTHR19290:SF99 (PTHR19290:SF99)