Protein atonal homologue 7 (IPR032663)

Short name: Atoh7

Overlapping homologous superfamilies

Family relationships



Protein atonal homologue 7 (Atoh7, also known as Math5) is a basic helix-loop-helix transcription factor that is involved in early stages of retinal neurogenesis [PMID: 9806930, PMID: 21441919]. It is specifically expressed in the embryonic neural retina and is required for the genesis of retinal ganglion cells (RGCs) and optic nerves [PMID: 22645276].

This entry also includes Xenopus atonal homologue 5 (Xath5), which is involved in the differentiation of retinal ganglion cells and olfactory receptor neurons [PMID: 12454929].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0003407 neural retina development
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.