Family

Protein atonal homologue 7 (IPR032663)

Short name: Atoh7

Overlapping homologous superfamilies

Family relationships

None.

Description

Protein atonal homologue 7 (Atoh7, also known as Math5) is a basic helix-loop-helix transcription factor that is involved in early stages of retinal neurogenesis [PMID: 9806930, PMID: 21441919]. It is specifically expressed in the embryonic neural retina and is required for the genesis of retinal ganglion cells (RGCs) and optic nerves [PMID: 22645276].

This entry also includes Xenopus atonal homologue 5 (Xath5), which is involved in the differentiation of retinal ganglion cells and olfactory receptor neurons [PMID: 12454929].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0003407 neural retina development
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER