Oligodendrocyte transcription factor 2 (IPR032658)

Short name: Olig2

Overlapping homologous superfamilies


Family relationships



Oligodendrocyte transcription factor 2 (Olig2) is a basic-helix-loop-helix (bHLH) transcription factor that is involved in motoneuron and oligodendrocyte development [PMID: 12121626]. Olig2 overexpression has been shown to enhance OPC (oligodendrocyte precursor cell) differentiation, maturation, and migration as well as remyelination following chemical demyelination. Therefore, OLIG2 overexpression in oligodendrocyte progenitor cells has been suggested to be a possible therapeutic mechanism for enhancing myelin repair [PMID: 25564492]. Olig2 shares structure and protein sequence similarity with Olig1, however, they have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes [PMID: 23165259].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0042552 myelination
GO:0030182 neuron differentiation
GO:0021778 oligodendrocyte cell fate specification
GO:0048709 oligodendrocyte differentiation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.