Family

Oligodendrocyte transcription factor 1 (IPR032657)

Short name: Olig1

Family relationships

None.

Description

Oligodendrocyte transcription factor 1 (Olig1) is a basic-helix-loop-helix (bHLH) transcription factor that promotes oligodendrocyte progenitor cell commitment, differentiation, and subsequent myelination primarily in brain, but not spinal cord [PMID: 25762682, PMID: 11955448]. Olig1 shares structure and protein sequence similarity with Olig2, however, they have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes [PMID: 23165259].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0048663 neuron fate commitment
GO:0048709 oligodendrocyte differentiation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER