Oligodendrocyte transcription factor 1 (IPR032657)

Short name: Olig1

Overlapping homologous superfamilies

Family relationships



Oligodendrocyte transcription factor 1 (Olig1) is a basic-helix-loop-helix (bHLH) transcription factor that promotes oligodendrocyte progenitor cell commitment, differentiation, and subsequent myelination primarily in brain, but not spinal cord [PMID: 25762682, PMID: 11955448]. Olig1 shares structure and protein sequence similarity with Olig2, however, they have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes [PMID: 23165259].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0048663 neuron fate commitment
GO:0048709 oligodendrocyte differentiation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.