Pathways & interactions
Oligodendrocyte transcription factor 1 (IPR032657)
Short name: Olig1
Overlapping homologous superfamilies
- Helix-loop-helix DNA-binding domain superfamily (IPR036638)
Oligodendrocyte transcription factor 1 (Olig1) is a basic-helix-loop-helix (bHLH) transcription factor that promotes oligodendrocyte progenitor cell commitment, differentiation, and subsequent myelination primarily in brain, but not spinal cord [PMID: 25762682, PMID: 11955448]. Olig1 shares structure and protein sequence similarity with Olig2, however, they have non-overlapping developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes [PMID: 23165259].
The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].
- PTHR19290:SF7 (PTHR19290:SF7)