Neurogenin-1 (IPR032653)

Short name: Ngn1

Overlapping homologous superfamilies

Family relationships



Neurogenin-1 (Ngn1, also known as neuroD3) is a basic helix-loop-helix transcription factor that is involved in neurogenesis [PMID: 18007592]. It interacts with other transcriptional regulators, such as Sox2, during neurogenesis [PMID: 23447599].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0022008 neurogenesis
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.