Pathways & interactions
Short name: Ngn1
Overlapping homologous superfamilies
- Helix-loop-helix DNA-binding domain superfamily (IPR036638)
Neurogenin-1 (Ngn1, also known as neuroD3) is a basic helix-loop-helix transcription factor that is involved in neurogenesis [PMID: 18007592]. It interacts with other transcriptional regulators, such as Sox2, during neurogenesis [PMID: 23447599].
The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].
- PTHR19290:SF130 (PTHR19290:SF130)