Neurogenic differentiation factor 1 (IPR032652)

Short name: Neurod1

Overlapping homologous superfamilies


Family relationships


Neurogenic differentiation factor 1 (Neurod1) is a basic helix-loop-helix (bHLH) transcription factor that is involved in neurogenesis [PMID: 18007592]. It has been found overexpressed in a variety of aggressive neural/neuroendocrine carcinomas [PMID: 23553831].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0048666 neuron development
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.