Neurogenic differentiation factor 6 (IPR032650)

Short name: Neurod6

Overlapping homologous superfamilies


Family relationships


Neurogenic differentiation factor 6 (Neurod6) is a basic helix-loop-helix (bHLH) transcription factor involved in the development and maintenance of the nervous system. It regulates cortical commissure formation before midline interactions during corpus callosum development [PMID: 23303943]. Neurod6 possesses mitochondrial biogenic properties by amplifying the mitochondrial DNA content and TFAM expression levels, a key regulator for mitochondrial biogenesis [PMID: 22814253]. Downregulation of NeuroD6 has been linked to Alzheimer's disease [PMID: 25548427, PMID: 26202100].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0007399 nervous system development
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.