Family

Neurogenic differentiation factor 6 (IPR032650)

Short name: Neurod6

Overlapping homologous superfamilies

None.

Family relationships

Description

Neurogenic differentiation factor 6 (Neurod6) is a basic helix-loop-helix (bHLH) transcription factor involved in the development and maintenance of the nervous system. It regulates cortical commissure formation before midline interactions during corpus callosum development [PMID: 23303943]. Neurod6 possesses mitochondrial biogenic properties by amplifying the mitochondrial DNA content and TFAM expression levels, a key regulator for mitochondrial biogenesis [PMID: 22814253]. Downregulation of NeuroD6 has been linked to Alzheimer's disease [PMID: 25548427, PMID: 26202100].

The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators [PMID: 12806077].

GO terms

Biological Process

GO:0007399 nervous system development
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER