Tumour protein p73 (IPR032646)

Short name: Tp73

Overlapping homologous superfamilies


Family relationships


Tumour protein p73 shares protein sequence similarity with the tumour suppressor p53 [PMID: 16601753]. It is involved in the apoptotic response to DNA damage [PMID: 11932750]. Human p73 has two isoforms, TA-isoforms that act as tumour-suppressors and DN-isoforms that behave as proto-oncogenes [PMID: 24983500]. p73 also plays a role in neuronal development and neurodegeneration [PMID: 21380933].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.