Transcription factor HES-7 (IPR032644)

Short name: HES-7

Overlapping homologous superfamilies


Family relationships



HES-7 is a bHLH-type repressor that is both a direct target of the Notch signalling pathway, and part of a negative feedback mechanism required to attenuate Notch signalling [PMID: 18775957, PMID: 11260262]. It can bind to its own promoter, thereby inhibiting its own transcription. In mouse its 3'UTR is essential for somite segmentation clock [PMID: 25248974]. Mutations in the HES-7 gene cause spondylocostal dysostosis, an inherited disorder characterised by the presence of extensive hemivertebrae, truncal shortening and abnormally aligned ribs [PMID: 18775957].

GO terms

Biological Process

GO:0007219 Notch signaling pathway
GO:0000122 negative regulation of transcription by RNA polymerase II

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.