Transcription factor SOX-2 (IPR032643)

Short name: SOX-2

Overlapping homologous superfamilies


Family relationships


SOX-2 belongs to the Sox family, which is a group of HMG box (high mobility group box) containing transcription factors. SOX-2 interacts with OCT4 (octamer-binding transcription factor 4) and is involved in stem cell pluripotency [PMID: 26314899]. It has been linked to cancers [PMID: 26159849, PMID: 26040981].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.