Exonuclease 1 (IPR032641)

Short name: Exo1

Overlapping homologous superfamilies


Family relationships


This entry represents exonuclease 1 (Exo1) from eukaryotes. Exo1 is a 5'-3' exonuclease that functions in DNA mismatch repair (MMR), double-strand break repair, replication and recombination [PMID: 16143102, PMID: 14676842, PMID: 12531018]. It also possesses a flap-endonuclease activity [PMID: 12531018, PMID: 10608837].

Budding yeast Exo1 has a paralogue known as Din7. Din7 is involved in mitochondrial DNA repair and replication [PMID: 12827502].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0035312 5'-3' exodeoxyribonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.