Domain

Protein argonaute, N-terminal (IPR032474)

Short name: Argonaute_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of argonaute proteins from eukaryotes. This domain is composed of an antiparallel four-stranded beta sheet core that has two alpha helices positioned along one face of the sheet and an extended beta strand towards its N terminus. The core fold of the N domain most closely resembles the catalytic domain of replication-initiator protein Rep. The N domain is linked to the PAZ domain via linker 1 region, and together these three regions are designated the PAZ-containing lobe of argonaute [PMID: 16061186].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam