Argonaute linker 2 domain (IPR032472)

Short name: ArgoL2

Overlapping homologous superfamilies


Domain relationships



ArgoL2 is the second linker domain in eukaryotic argonaute proteins. It starts with two alpha-helices aligned orthogonally to each other followed by a beta-strand involved in linking the two lobes, the PAZ lobe and the Piwi lobe of argonaute to each other. Linker 2 together with the N, PAZ and L1 domains form a compact global fold [PMID: 16061186]. Numerous residues from Piwi, L1 and L2 linkers direct the path of the phosphate backbone of nucleotides 7-9, thus allowing DNA-slicing [PMID: 23746446].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.