Domain

Keratin type II cytoskeletal 1, tail (IPR032449)

Short name: Keratin_2_1_tail

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

All intermediate filament proteins feature a central alpha-helical rod domain and variable nonhelical domains located at the N-terminal (head) and C-terminal (tail). The central rod domain is the main driver of self-assembly into filaments, whereas the N- and C-terminal domains are involved in post-translational modifications and interactions with other proteins [PMID: 16710422]. Keratin 1 (KRT1) belongs to a large family of intermediate filament protein genes and is normally expressed in keratinocytes in the spinous layer of the epidermis [PMID: 12711220]. This entry represents the C-terminal domain (tail) of type II keratin KRT1.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam