Domain

Keratin type II head (IPR032444)

Short name: Keratin_2_head

Domain relationships

None.

Description

All intermediate filament proteins feature a central alpha-helical rod domain and variable nonhelical domains located at the N-terminal (head) and C-terminal (tail). The central rod domain is the main driver of self-assembly into filaments, whereas the N- and C-terminal domains are involved in post-translational modifications and interactions with other proteins [PMID: 16710422]. Type I and type II keratin form heteropolymeric intermediate filaments providing vital mechanical support in epithelia [PMID: 22705788]. This entry represents the N-terminal domain (head) of type II keratins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam