RAWUL domain (IPR032443)

Short name: RAWUL

Overlapping homologous superfamilies


Domain relationships



The RAWUL domain is found at the C terminus of poly-comb group RING finger proteins. It contains a variant ubiquitin-like fold with a distinct conserved surface region. The conserved surface found in this domain is responsible for interaction with Cbx members of the PRC1 (polycomb repression complex 1) and homodimer formation [PMID: 19791798].

The RAWUL domain binds directly to PUFD, a domain on BCOR proteins (BCL6 corepressor). BCOR has emerged as an important player in development and health [PMID: 23523425].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.