Domain

Talin, N-terminal F0 domain (IPR032425)

Short name: FERM_f0

Domain relationships

None.

Description

This domain (F0), found in the talin head, forms a stable globular structure. The fold is an ubiquitin-like fold joined to the F1 domain in a novel fixed orientation by an extensive charged interface. It is required for maximal integrin-activation [PMID: 20150896].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam