Domain

Huntingtin-interacting protein 1, clathrin-binding domain (IPR032422)

Short name: HIP1_clath-bd

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the coiled-coil region of Huntingtin-interacting protein 1 (HIP1). It carries a highly conserved HADLLRKN sequence motif at its N terminus which effects the binding of HIP1R to clathrin light-chain EED regulatory site. This binding then stimulates clathrin lattice assembly. HIP1 is an obligate binding partner for Huntingtin, and loss of this interaction triggers the cascade of events that results in the apoptosis of neuronal cells and the onset of Huntington's disease [PMID: 17257618]. Clathrin light-chain binds to a flexible coiled-coil domain in HIP1 and induces a compact state that is refractory to actin binding [PMID: 20179344].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam