Domain

Stromal interaction molecule, Orai1-activating region (IPR032393)

Short name: SOAR

Domain relationships

None.

Description

This domain, also known as SOAR, is the Orai1-activating region of STIM1 (stromal interaction molecule 1). STIM1 is a Ca2+ sensor in the endoplasmic reticulum. As the store of calcium is depleted the calcium sensor in the ER activates Orai1, a Ca2+-release-activated Ca2+ (CRAC) channel, in the plasma membrane. The SOAR region forms a dimer, and is essential for oligomerisation of the whole of STIM1 [PMID: 22451904].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
Pfam