Domain

SATB, ubiquitin-like oligomerisation domain (IPR032392)

Short name: ULD

Domain relationships

None.

Description

This entry represents the N-terminal oligomerisation domain, also known as ULD domain, of the SATB (special AT-rich sequence-binding) protein. SATBs are global chromatin organisers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerisation of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity [PMID: 22241778].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam