Domain

FOXP, coiled-coil domain (IPR032354)

Short name: FOXP-CC

Domain relationships

None.

Description

This coiled-coil domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins from animals [PMID: 14516685]. It modulates the dimeric associations of FOXP transcription factors. Several mutations found in this domain have been linked to the IPEX syndrome (immunodysregulation polyendocrinopathy enteropathy X-linked syndrome) [PMID: 22813742].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam