Cell-cycle alteration and expression-elevated protein in tumour (IPR032337)

Short name: CREPT

Overlapping homologous superfamilies


Family relationships



CREPT (Cell-cycle alteration and expression-elevated protein in tumour), also known as RPRD (regulation of nuclear pre-mRNA domain-containing protein) is a family of eukaryotic transcriptional regulators that promote the binding of RNA-polymerase to the CYCLIN D1, CCDN1, promoter and other genes involved in the cell-cycle [PMID: 22231121]. It promotes the formation of a chromatin loop in the CYCLIN D1 gene, and is preferentially expressed in a range of different human tumours [PMID: 22264791].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.