Sam68, tyrosine-rich domain (IPR032335)

Short name: Sam68-YY

Overlapping homologous superfamilies


Domain relationships



This entry represents a tyrosine-rich domain found in Sam68, also known as KH domain-containing, RNA-binding, signal transduction-associated protein. Sam68 regulates TCF-1 alternative splicing. It is a crucial binding-partner of the APC-Arm domain that forms a superhelix with a positively charged groove, the surface-residues of which groove form numerous interactions with this domain to fix it in a bent conformation. APC-Arm is the armadillo repeat domain of the tumour-suppressor protein adenomatous polyposis coli or APC. APC plays plays important roles in Wnt signalling and other cellular processes [PMID: 22000517].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.