Domain

THO complex subunit 2, N-terminal domain (IPR032302)

Short name: THOC2_N

Domain relationships

None.

Description

This entry represents the N terminus of THO complex subunit 2 (THO2, THOC2) [PMID: 15998806, PMID: 11060033].

THO/TREX, a nuclear protein complex conserved from yeast to humans, plays an important role in mRNP biogenesis connecting transcription elongation, mRNA export and preventing genetic instability. THO could be relevant to different mRNA processing steps, including the 3'-end formation, transcript release and export [PMID: 22207203].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam