Domain

Niemann-Pick C1, N-terminal (IPR032190)

Short name: NPC1_N

Domain relationships

None.

Description

This is the N-terminal domain of Niemann-Pick C1 family proteins, which mediate transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket [PMID: 10783261, PMID: 21525977].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam