Domain

Axin-1/2, tankyrase-binding domain (IPR032101)

Short name: Axin_TNKS-bd

Domain relationships

None.

Description

This is the N-terminal tankyrase binding domain described for Axin-1 [PMID: 22307604].

Axin (axis inhibition protein) is a scaffold protein that is involved in many signalling pathways, including the Wnt, transforming growth factor-beta, MAP kinase pathways, as well as p53 activation cascades [PMID: 18316368, PMID: 15067197]. It controls many biological processes ranging from sugar intake, cell proliferation, and organ development to cell death [PMID: 15067197].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
Pfam