Domain

Fibronectin type III domain-containing protein 5, C-terminal domain (IPR032073)

Short name: FNDC5_C

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This domain is found in fibronectin type III domain-containing protein 5 (FNDC5). FNDC5 is cleaved into Irisin, a putative myokin that stimulates white-to-brown fat conversion in mice [PMID: 22237023], though this role is disputed in humans [PMID: 24781257, PMID: 26212086]. This domain is found C-terminal to the irisin domain [PMID: 24114836].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam