Ubiquitin carboxyl-terminal hydrolase 37, pleckstrin homology-like domain (IPR032069)

Short name: USP37-like_PH

Overlapping homologous superfamilies

Domain relationships



This entry represents a pleckstrin homology (PH)-like domain found at the N terminus of some ubiquitin carboxyl-terminal hydrolases, including USP26, USP29 and USP37. USP37 antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), resulting in promoting S phase entry [PMID: 21596315]. USP26 is a regulator of androgen receptor (AR) signaling [PMID: 20501646]. Both USP26 and USP37 are critical for double-strand breaks repair by homologous recombination [PMID: 26101254]. USP29 plays a role in apoptosis and oxidative stress [PMID: 21285945].

PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner [PMID: 22728242]. They share little sequence conservation, but all have a common fold, which is electrostatically polarized.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.