Domain

Paf1 complex subunit Cdc73, N-terminal domain (IPR032041)

Short name: Cdc73_N

Domain relationships

None.

Description

This is the N-terminal region of Cdc73 (cell division cycle 73). Cdc73 forms part of the Paf1 post-initiation complex [PMID: 9891041]. As part of the Paf1 complex, Cdc73 associates with RNA-polymerase II and is involved in several transcriptional and posttranscriptional events. In vertebrates, the protein encoded by HRPT2/CCdc73 is known as Parafibromin, and acts as a tumour suppressor [PMID: 15580289, PMID: 16989776].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam