Domain

Adenomatous polyposis coli, N-terminal dimerisation domain (IPR032038)

Short name: APC_N

Domain relationships

None.

Description

This entry represents the N-terminal, coiled-coil dimerisation domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin [PMID: 10926498].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam