Solute carrier family 3 member 2, N-terminal domain (IPR031984)

Short name: SLC3A2_N

Overlapping homologous superfamilies


Domain relationships



Heteromeric amino acid transporters (HATs) are composed of two subunits, a heavy (SLC3 family) and a light subunit [SLC7 or L-type amino acid transporter (LAT) family] linked by a conserved disulfide bridge [PMID: 23506863]. HATs are amino acid exchangers, and the transport activity resides in the light subunit. The heavy chain of the surface antigen 4F2 (4F2hc), also known as solute carrier family 3 member 2 protein (Slc3a2), is a HAT heavy subunit [PMID: 9915839, PMID: 24516142]. 4F2hc controls the cell surface expression as well as the membrane topology of the 4F2 heterodimer [PMID: 9915839].

This entry represents the N-terminal domain of 4F2hc.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.