Domain

Sharpin, PH domain (IPR031912)

Short name: Sharpin_PH

Overlapping homologous superfamilies

Domain relationships

None.

Description

This PH domain is found at the N terminus of sharpin and is involved in dimerisation. Sharpin is part of the LUBAC complex, a large multi-protein E3 ubiquitin ligase complex that catalyses the formation of linear ubiquitin chains and regulates immune and apoptopic signalling pathways [PMID: 22549881].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam