F-box only protein 30/40 (IPR031890)

Short name: Fbxo30/Fbxo40

Overlapping homologous superfamilies


Family relationships



This entry includes F-box only protein 30 (Fbxo30) [PMID: 24076600] and F-box only protein 40 (Fbxo40) [PMID: 17928169]. Fbxo30 is a ubiquitin ligase required for muscle loss, hence it is also known as muscle ubiquitin ligase of the SCF complex in atrophy-1 (MUSA1) [PMID: 24076600]. Fbxo40 id an E3 ubiquitin ligase that induces IRS1 ubiquitination and breakdown specifically in skeletal muscle cells and only upon IGF1 (insulin-like growth factor 1) stimulation [PMID: 22033112].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0061630 ubiquitin protein ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.