Domain

MiT/TFE transcription factors, N-terminal (IPR031867)

Short name: MiT/TFE_N

Domain relationships

None.

Description

This entry represents a domain found at the N terminus of the MiT/TFE family members, which include MITF (microphthalmia-associated transcription factor) and its related family members TFE3, TFEB and TFEC [PMID: 7958932]. They are basic helix-loop-helix leucine zipper transcription factors found in chordata. These transcription factors heterodimerize with each other and bind to the E-box core sequence (3'-CANNTG-5') [PMID: 15507434, PMID: 26240184].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam