Domain

Gap junction alpha-5 protein (Cx40), C-terminal (IPR031862)

Short name: Cx40_C

Overlapping homologous superfamilies

Domain relationships

None.

Description

This entry represents the C-terminal domain of connexin 40 (Cx40). It interacts with the C-terminal and cytoplasmic loop domains of connexin 43 and with the cytoplasmic loop of another connexin 40 [PMID: 19808665].

Connexin 40 is a gap junction protein that has been linked to lone atrial fibrillation [PMID: 24733048]. Gap junctions is composed of two hemichannels, each constituted by the oligomerisation of six connexins (Cx). This junction allows direct exchange of ions and small molecules between apposing cells [PMID: 24733048].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam