Domain

E3 ubiquitin-protein ligase RNF220, middle domain (IPR031824)

Short name: RNF220_mid

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the central region of the E3 ubiquitin-protein ligase RNF220 [PMID: 20170641]. RNF220 also interacts with beta-catenin independently of its E3 ligase activity; instead of ubiquitinating and destabilising it, RNF220 promotes beta-catenin stabilisation and canonical Wnt signaling [PMID: 25266658]. Proteins containing this domain also include Drosophila Tey protein and some uncharacterised fungal proteins. Tey (Teyrha-Meyhra) is a transcription factor that suppresses Toll expression [PMID: 20504957].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam