Domain

Fanconi anaemia group A protein, N-terminal domain (IPR031729)

Short name: Fanconi_A_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Fanconi anemia (FA) is a human disorder characterized by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination. It is required for the monoubiquitylation of FANCD2 and FANCI heterodimer. The FA core complex consists of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, FANCM, FANCT (UBET2), FAAP100 and FAAP24 [PMID: 29017571, PMID: 20347428].

This entry represents the N-terminal domain of FANCA.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam