Domain

Homeobox protein SIX1, N-terminal SD domain (IPR031701)

Short name: SIX1_SD

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The SD domain is found N-terminal to the homeobox domain in the protein SIX1. As a transcription factor, SIX1 lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. The SD domain is necessary for this protein-protein interaction, binding to the C-terminal region of EYA (Eyes absent homologue proteins) [PMID: 23435380].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam