Loricrin (IPR031700)

Short name: Loricrin

Overlapping homologous superfamilies


Family relationships



Loricrin is a major keratinocyte cell envelope protein [PMID: 2007607]. The cornified cell envelope is a structure that replaces the plasma membrane during keratinocyte terminal differentiation. Loricrin acts as an important epidermal barrier, comprising 70% of the total protein mass of the cornified layer. Expression of Loricrin is regulated by TNF-alpha via a c-Jun N-terminal kinase-dependent pathway [PMID: 21346775]. Loricrin mutations cause the Vohwinkel syndrome [PMID: 12072018] and other congenital skin abnormalities collectively termed as loricrin keratoderma [PMID: 12615358].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0030280 structural constituent of epidermis

Cellular Component

GO:0001533 cornified envelope

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.