TSSK6-activating co-chaperone protein (IPR031679)

Short name: SSTK-IP

Overlapping homologous superfamilies


Family relationships



SSTK-IP, SSTK-interacting protein or TSSK6-activating co-chaperone, is a family of proteins found in eukaryotes. SSTK-IP directly binds to HSP70, is found associated with HSP70 and HSP90 in cells, and facilitates HSP90-dependent enzymatic activation of SSTK. SSTK is a small serine/threonine kinase expressed post-meiotically and essential for male fertility along with two other serine threonine kinases. SSTK is one of the smallest protein kinases, consisting only of N- and C-lobes of a kinase catalytic domain, and forms stable associations with heat shock protein (HSP) 70 and 90. SSTK-IP, its interacting protein, represents a germ cell-specific co-chaperone critical to the HSP90-mediated activation of SSTK [PMID: 20829357].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0051087 chaperone binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.